Stem Cell Applications

Stem Cell Applications

STEM CELL APPLICATION AREAS:

  • Regenerative Medicine

  • Plastic Surgery

  • General Surgery

  • Orthopedics

  • Dermatology

  • Cardiovascular Surgery

  • Hematology

  • Gastroenterology

  • Chest Diseases and Surgery

  • Oncology

  • Obstetrics

  • Endocrinology

  • ENT

  • Ophthalmology

  • Neurology

STEM CELL APPLICATIONS:

Today, developments in the diagnosis and treatment of diseases continue at a dizzying pace. Despite these developments in modern medicine, there are some disease groups for which these latest methods are not effective in the definitive treatment; All autoimmune diseases with increasing frequency such as type 1 diabetes, multiple sclerosis (MS) and rheumatoid arthritis, Amyotrophic lateral sclerosis (ALS), which is a deadly disease whose exact cause is still unknown, and which require transplantation from a living donor for definitive treatment. insufficiency of organs such as heart, liver and kidney, diseases such as deafness and blindness without a genetic basis, paralysis resulting from spinal cord damage at various levels, cerebrospinal ataxias characterized by balance disorders, neurodegenerative diseases such as Alzheimer's and Parkinson's

  • Stem cell applications have emerged as a promising approach to Crohn's disease, (chronic inflammatory bowel disease) with effects on the digestive system. Crohn's disease causes inflammation, ulcers, and other complications in the digestive tract, leading to symptoms such as abdominal pain, diarrhea, and fatigue.

    Stem cells are unique cells that can differentiate into various cell types in the body and have regenerative properties. In the context of Crohn's disease, stem cell applications involve the use of either the patient's own stem cells (autologous) or stem cells derived from a donor (allogeneic) aimed at repairing damaged tissues and regulating the immune response.

    Autologous stem cell transplantation begins with the removal of stem cells from the patient's bone marrow, adipose tissue or peripheral blood. These cells are then processed and purified in the laboratory and then reintroduced into the patient's body. Allogeneic stem cell transplantation, on the other hand, involves the use of stem cells obtained from a compatible donor.

    The transplanted stem cells can migrate to areas of the digestive tract where there is inflammation and differentiate into different cell types involved in the repair of damaged tissues. Also, stem cells have immunomodulatory properties, so they can help regulate the impaired immune response in Crohn's disease.

    Many studies and clinical trials have shown promising results of stem cell applications in Crohn's disease. Scientific results show that stem cell application can help reduce inflammation, promote tissue healing, and improve patients' overall disease symptoms and quality of life.

    Stem cell applications for Crohn's disease are still an active area of ​​research. Applications are limited to certain cases that do not respond to conventional treatments. The success rate may vary from person to person and depending on the condition of the disease.

  • Ulcerative colitis is a chronic bowel disease that causes inflammation of the large intestine (colon) and rectum. This disease causes recurrent and persistent symptoms such as bloody diarrhea, abdominal pain, weight loss and fatigue. In some ulcerative colitis patients who do not respond to conventional treatments or have severe symptoms, stem cell application may be a promising option.

    Stem cell application aims to repair tissue damage and regulate the immune system in ulcerative colitis patients. This method of treatment may involve using the patient's own stem cells (autologous) or stem cells from a compatible donor (allogeneic).

    Autologous stem cell administration begins with the collection of stem cells from the patient's bone marrow or peripheral blood. These cells can be processed in the laboratory, purified, and then frozen before being returned to the patient. In the application of allogeneic stem cells, stem cells from a compatible donor are used.

    Stem cells can promote remodeling and healing in the intestinal tissue to which they are administered. They may also suppress inflammation by reducing the overactivity of the immune system. In this way, it is aimed to reduce the symptoms of ulcerative colitis, to control the course of the disease and to increase the quality of life of the patients.

    Stem cell application for ulcerative colitis is still in the experimental stage and there is no fully understood mechanism. However, some clinical studies and trials show that stem cell administration can provide positive results such as reduction of symptoms and prolongation of remission in ulcerative colitis patients.

    Stem cell administration is a complex approach that requires an individual assessment for each patient. It is important that patients are informed in detail about the potential benefits and risks of stem cell application and that they are treated under the supervision of a specialist medical team. The success rate in Stem Cell applications may vary from person to person and depending on the condition of the disease.

  • Cirrhosis is a condition characterized by persistent damage and scar tissue formation in the liver. This disease can occur due to alcohol-induced liver disease, hepatitis, or other factors. As cirrhosis progresses, liver cells lose function and liver failure occurs. Liver failure can lead to disruption of many important functions in the body and serious complications.

    Hepatic encephalopathy is a dysfunction in the brain due to liver failure. Toxic substances that the liver normally filters and removes waste products accumulate in the brain and can affect the nervous system. As a result, symptoms such as memory problems, behavioral changes, sleep disturbances and even loss of consciousness can occur.

    Stem cell application may be a promising option in the treatment of conditions such as cirrhosis, hepatic encephalopathy and liver failure. Stem cells are cells that have a special ability and can turn into different cell types. In the case of liver failure, the potential of stem cells can be used to repair damaged liver tissue and improve liver function.

    Stem cell application is usually performed by using the patient's own stem cells (autologous). This process begins with the collection of stem cells from the patient's bone marrow or blood. The collected stem cells are processed in the laboratory and then given to the patient again. Stem cells can promote remodeling in the liver tissue to which they are transplanted and support the healing of damaged cells.

    Stem cell administration for cirrhosis, hepatic encephalopathy and liver failure has the potential to improve liver function. However, stem cell application is still an active area of ​​research and is not a fully understood treatment modality. Studies and clinical trials show that stem cell administration has the potential to reduce liver damage, promote remodeling and improve symptoms.

    Stem cell application is a complex method that requires an individual evaluation according to each patient's condition. It is important that patients are informed in detail about the potential benefits and risks of stem cell application and that the applications are carried out under the supervision of a specialist medical team. The success rate in Stem Cell applications may vary from person to person and depending on the condition of the disease.

Inflammatory Bowel Diseases

  • Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which nerve cells are gradually destroyed and affect muscle control. As this disease progresses, muscle strength and mobility decrease, problems such as speech and swallowing difficulties occur, and eventually it can become life-threatening with respiratory muscles being affected.

    Stem cell applications are being explored as a promising treatment option in ALS patients. Stem cells are cells that have a special ability and can turn into different cell types. In the case of ALS, the potential of stem cells can be harnessed to repair damaged nerve cells, reduce inflammation and promote nerve communication.

    Stem cell administration for ALS is usually performed using the patient's own stem cells (autologous). This process begins with the collection of stem cells from the patient's bone marrow or blood. The collected stem cells are processed in the laboratory and then given to the patient again. Stem cells can help repair and rebuild damaged nerve cells in the area where they are transplanted.

    Stem cell administration may have the potential to slow the course of ALS and relieve symptoms. However, stem cell application is not yet a fully understood and definitive treatment method. Research on the effectiveness of stem cells in the treatment of ALS continues.

    Timing is also important, as ALS is a rapidly progressive disease. Applying for stem cell application in the early stages can increase the chances of getting better results.

    Stem cell administration for ALS patients is a complex process that requires an individual assessment for each patient. It is important that patients are informed in detail about the potential benefits and risks of stem cell application and that the process is carried out under the supervision of an experienced medical team.

  • Autism spectrum disorder (ASD) is a neurodevelopmental disorder that typically begins in early childhood and causes difficulties in social interaction, communication, and behavior. Autism can appear differently in each individual, and symptoms can vary widely. Although the cause of autism spectrum disorder is not fully understood, it is thought to be related to disorders in neural connections and communication in the brain.

    Stem cell application is being investigated as a promising treatment option in individuals with autism spectrum disorders. Stem cells are cells that have a special ability and can turn into different cell types. In the case of autism, the potential of stem cells can be used to repair neural connections, reduce inflammation in the brain.

    Stem cell application is usually performed using the patient's own stem cells (autologous). This process begins with the collection of stem cells from the patient's bone marrow or adipose tissue. The collected stem cells are processed in the laboratory and then given back to the patient. Stem cell application has the potential to repair neural connections and improve brain function.

    However, in the case of autism, stem cell application is not yet a fully understood and definitive treatment method. Because autism spectrum disorder is a complex disorder, each individual's response to the practice may be different. Research and clinical trials show that stem cell application can alleviate autism symptoms and contribute to the development of behavior, communication and social skills in some individuals.

    Stem cell administration for individuals with autism spectrum disorder is a complex process that requires an individual assessment for each individual. It is important that patients are informed in detail about the potential benefits, risks and limitations of stem cell administration and that the process is carried out under the supervision of an experienced medical team.

    Autism spectrum disorder is a condition that requires a multidisciplinary approach and stem cell application may be only one component of this approach. It is important for families to collaborate with a healthcare professional to determine the most appropriate treatment plan for their child's needs.

  • Cerebral Palsy (CP) refers to a group of permanent movement and posture disorders due to brain damage or abnormalities in brain development. CP usually results from brain damage that occurs during birth or early childhood. This condition can affect muscle control, movement ability, and sometimes speech.

    Stem cell applications are being researched as a promising treatment option for individuals with cerebral palsy. Stem cells are cells in the body that can turn into different cells and have regenerative properties. In the case of cerebral palsy, the potential of stem cell applications can be used to repair damaged areas in the brain, restructure nerve cells, and improve functions.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are collected from the patient's bone marrow or adipose tissue. The collected stem cells are processed in a laboratory and then injected into damaged areas. Stem cells can promote regeneration in the area where they are transplanted, support tissue healing, and promote the development of motor functions.

    However, stem cell applications in cerebral palsy are not yet a treatment method that is fully understood and can provide definitive results. Since every individual's situation is different, the effectiveness of the treatment can vary from person to person. Research and clinical trials show that stem cell applications can alleviate cerebral palsy symptoms, enhance movement ability, and improve quality of life.

    Stem cell applications for individuals with cerebral palsy are a process that requires individual evaluation for each individual. It is important that patients and families are fully informed about the potential benefits, risks, and limitations of stem cell applications, and that the treatment process is carried out under the supervision of a professional medical team.

    Stem cell applications in the treatment of cerebral palsy should be considered along with other treatment approaches and managed with a multidisciplinary approach. The best results can be achieved when used in combination with other rehabilitation programs such as physiotherapy, speech therapy, and occupational therapy.

  • Alzheimer's disease is a progressive neurodegenerative disease that manifests itself with symptoms such as memory loss, cognitive disorders, and behavioral changes. This disease results from the damage and death of nerve cells in the brain. Alzheimer's generally occurs in advanced age and starts with memory loss, which can then lead to more serious problems such as loss of thinking ability, language skills, and daily functions.

    Stem cell applications are being researched as a promising treatment option for individuals with Alzheimer's disease. Stem cells are cells in the body that can turn into different cells and have regenerative properties. In Alzheimer's, the potential of stem cell applications can be used to repair damaged areas in the brain, restructure nerve cells, and improve nerve communication.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are collected from the patient's bone marrow or adipose tissue. The collected stem cells are processed in a laboratory and then injected into damaged areas in the brain. Stem cells can promote regeneration in the area where they are transplanted, reduce inflammation, and support the health of nerve cells.

    However, stem cell applications in Alzheimer's disease are not yet a treatment method that is fully understood and can provide definitive results. Since Alzheimer's disease is a complex disease, the response of each individual to the treatment can be different. Research and clinical trials show that stem cell applications can alleviate Alzheimer's symptoms, improve brain functions, and enhance quality of life.

    Stem cell applications for individuals with Alzheimer's disease are a process that requires individual evaluation for each individual. It is important that patients and families are fully informed about the potential benefits, risks, and limitations of stem cell applications, and that the treatment process is carried out under the supervision of a professional medical team.

    Stem cell applications do not guarantee stopping or completely curing the progression of Alzheimer's disease. However, they can potentially alleviate symptoms and enhance quality of life. It is important to access the most up-to-date information on Alzheimer's disease and to consult with a specialist doctor about treatment options.

  • Multiple Sclerosis (MS) is an autoimmune disease that occurs in the central nervous system (brain and spinal cord). In this disease, the immune system mistakenly attacks the body's own nerve cells, leading to inflammations that affect nerve transmission. MS usually appears in young adults and symptoms can include fatigue, balance problems, muscle weakness, visual problems, and cognitive disorders.

    Stem cell applications are being researched as a promising treatment option for MS patients. Stem cells are cells in the body that can turn into different cells and have regenerative properties. In the case of MS, the potential of stem cell applications can be used to regulate the immune system, reduce inflammation, and repair damaged nerve tissue.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are collected from the patient's bone marrow or blood. The collected stem cells are processed in a laboratory and then injected into damaged areas. Stem cells can reduce inflammation in the area where they are transplanted, promote regeneration, and regulate nerve transmission.

    However, in the case of multiple sclerosis, stem cell applications are not yet a treatment method that is fully understood and can provide definitive results. Since every individual's disease course is different, the effectiveness of the treatment can vary from person to person. Research and clinical trials show that stem cell applications can alleviate MS symptoms, reduce relapses, and enhance quality of life.

    Stem cell applications for MS patients are a process that requires individual evaluation for each individual. It is important that patients and families are fully informed about the potential benefits & risks

Neurological Diseases

  • Systemic lupus erythematosus (SLE) is an autoimmune disease and the body's immune system starts attacking its own cells. SLE can affect a variety of organs, particularly the skin, joints, kidneys, heart and lungs. Symptoms may include skin rashes, joint pain, fatigue, fever, kidney problems and muscle aches. SLE is more common in younger women.

    Stem cell applications are being investigated as a potential treatment option for patients with systemic lupus erythematosus. Stem cells are cells that can transform into different cells in the body and have regenerative properties. In the case of SLE, the potential of stem cell applications can be exploited to regulate autoimmune responses, reduce inflammation and repair damaged tissue.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are collected from the patient's bone marrow or blood. The collected stem cells are processed in the laboratory and then injected into the damaged areas of the patient's body. Stem cells can reduce inflammation, promote regeneration and support tissue repair in the area where they are transplanted.

    However, in the case of systemic lupus erythematosus, stem cell applications are not yet a fully understood and definitive treatment method. Since the course of the disease is different for each individual, the effectiveness of the treatment may vary from person to person. Research and clinical trials show that stem cell applications can alleviate the symptoms of SLE, slow the progression of the disease and improve the quality of life.

    Stem cell applications for SLE patients is a process that requires an individual evaluation for each individual. It is important that patients and families are informed in detail about the potential benefits, risks and limitations of stem cell applications and that the treatment process is carried out under the supervision of a specialist medical team.

    Please note that stem cell treatments do not guarantee a complete cure for SLE. It is important to get the most up-to-date information about SLE and to talk to a specialist doctor about treatment options.

Rheumatological Diseases

  • Decreased ovarian reserve is a condition in which female fertility potential is reduced. In this case, ovarian reserve (the number of eggs in the ovaries) may be reduced or ovarian function may be impaired. Decreased ovarian reserve can naturally reduce the chance of pregnancy and cause infertility.

    Stem cell applications are being investigated as a promising treatment option in women with reduced ovarian reserve. Stem cells are cells that can transform into different cells in the body and have regenerative properties. Studies on ovarian tissue show that stem cells have potential for egg production and repair of ovarian tissue.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are collected from the patient via bone marrow or blood. The collected stem cells are processed in the laboratory and then injected into the ovaries. Stem cells can help repair ovarian tissue and stimulate the formation of new eggs.

    However, in the case of decreased ovarian reserve, stem cell applications are not yet a fully understood and definitive treatment method. Since each individual's situation is different, the effectiveness of treatment may vary from person to person. Studies and clinical studies show that stem cell applications can increase egg production and improve fertility potential in some women with reduced ovarian reserve.

    Stem cell applications for women with reduced ovarian reserve is a process that requires an individual evaluation for each individual. It is important that patients are informed in detail about the potential benefits, risks and limitations of stem cell applications and that the treatment process is carried out under the supervision of a specialist medical team.

    Please note that stem cell applications do not guarantee a complete cure for decreased ovarian reserve. It is important to get the most up-to-date information on fertility and to talk to a specialist doctor about treatment options.

  • Thin Endometrium and Asherman syndrome are two conditions common among women and can cause fertility problems. Thin Endometrium is the condition where the thickness of the endometrium layer, which is the inner surface of the uterus, is less than normal. Asherman's syndrome, on the other hand, is the effect of the endometrium as a result of the formation of adhesions in the uterus. Both conditions can reduce or prevent pregnancy chances.

    Stem cell applications are being explored as a promising treatment option in women with Thin Endometrium and Asherman's syndrome. Stem cells are cells that can transform into different cells in the body and have regenerative properties. Stem cells have potential in the repair and restructuring of the endometrium, the inner surface of the uterus.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are collected from the patient's bone marrow or adipose tissue. The collected stem cells are processed in the laboratory and then injected into the inner surface of the uterus. Stem cells can promote the repair of the endometrium, support the formation of new cells and improve the internal structure of the uterus.

    However, in the case of Thin Endometrium and Asherman's syndrome, stem cell applications are not yet a treatment method that is fully understood and definitive results can be obtained. Since each individual's situation is different, the effectiveness of treatment may vary from person to person. Studies and clinical studies show that stem cell applications can increase the thickness of the endometrium, reduce adhesions and improve fertility potential in some women with Thin Endometrium and Asherman syndrome.

    Stem cell applications for women with Thin Endometrium and Asherman syndrome is a process that requires an individual assessment for each individual. It is important that patients are informed in detail about the potential benefits, risks and limitations of stem cell applications and that the treatment process is carried out under the supervision of a specialist medical team.

    Please note that stem cell treatments do not guarantee a complete cure for Thin Endometrium and Asherman's syndrome. It is important to get the most up-to-date information on fertility and to talk to a specialist doctor about treatment options.

Gynecological Diseases

Urological Diseases

  • Erectile dysfunction is a condition known as sexual dysfunction in men. In this case, the ability to achieve or maintain an erection is affected, making sexual intercourse difficult or impossible. Erectile dysfunction can be caused by many factors, such as aging, chronic diseases, hormonal imbalances, stress or psychological factors.

    Stem cell applications are being explored as a promising treatment option for men with erectile dysfunction. Stem cells are cells that can transform into different cells in the body and have regenerative properties. Stem cells, which have the potential to treat erectile dysfunction, can help repair and rebuild tissues.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are collected from the patient's fat tissue or bone marrow. The collected stem cells are processed in the laboratory and then injected into the area where sexual function is regulated. Stem cells can increase blood flow to the penis, promote tissue healing and help restore erectile function.

    However, in the case of erectile dysfunction, stem cell applications are not yet a fully understood and definitive treatment method. Since each individual's situation is different, the effectiveness of treatment may vary from person to person. Research and clinical studies show that stem cell applications can improve erectile function in some men.

    Stem cell applications for men with erectile dysfunction is a process that requires an individual assessment for each individual. It is important that patients are informed in detail about the potential benefits, risks and limitations of stem cell applications and that the treatment process is carried out under the supervision of a specialist medical team.

    Please note that stem cell treatments do not guarantee a complete cure for erectile dysfunction. It is important to get the most up-to-date information on sexual health and to talk to a specialist doctor about treatment options.

  • Osteoarthritis is a joint disease that occurs due to wear and degeneration of the articular cartilage. This can cause joint pain, stiffness, limitation of movement, and loss of function. Osteoarthritis is often associated with aging, joint injuries, overweight, genetic factors, and joint inflammation.

    Stem cell applications are being investigated as a promising method in the treatment of osteoarthritis. Stem cells, which have the potential to repair cartilage damage caused by osteoarthritis and help regenerate joint tissue, can support the natural healing process.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are collected from the patient's bone marrow or adipose tissue. The collected stem cells are processed in the laboratory and then injected into the damaged joint area. Stem cells promotes:

    • cartilage tissue regeneration

    • reduce inflammation

    • improve joint function.

  • Nonunion fractures are conditions in which bone fractures do not heal for a longer period of time than expected. This condition can be caused by factors that prevent bones from joining naturally, such as poor circulation, infection, displacement of bone fragments, or another disease that affects bone union.

    Stem cell applications are being explored as a promising option in the treatment of nonunions. Stem Cells, which can transform into different cells in the body with the potential to support bone reabsorption, can help repair and heal bone tissue.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). Stem cells, usually collected from the patient’s bone marrow, are processed in the laboratory and then injected into the nonunion site. Stem cells can stimulate the formation of bone cells, support the formation of new blood vessels and speed up the healing process.

  • Avascular necrosis is a condition in which tissue dies as a result of reduced or complete cessation of blood flow to a bone or joint. This condition usually occurs because the bones are not getting enough oxygen and nutrients. Avascular necrosis can cause symptoms such as pain, joint stiffness, and limitation of movement.

    Stem cell applications are being explored as a promising option in the treatment of avascular necrosis. Stem cells are cells that can transform into different cells in the body and have regenerative properties. Stem cells, which have the potential to repair damage caused by avascular necrosis and promote the formation of new blood vessels, can support tissue remodeling.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are collected from the patient's bone marrow or adipose tissue. The collected stem cells are processed in the laboratory and then injected into the area of ​​avascular necrosis. Stem cells can promote tissue healing by promoting the formation of new blood vessels.

  • Degenerative disc disease is a condition that results from degenerative changes in the discs of the spine. Discs are structures located between the vertebrae that provide the flexibility of the spine. This disease is often associated with the aging process and can cause symptoms such as pain, stiffness, and limitation of movement.

    Stem cell applications are being explored as a promising option in the treatment of degenerative disc disease. Stem cells are cells that can transform into different cells in the body and have regenerative properties. Stem cells, which have the potential to repair damage from degenerative disc disease and promote the healing of discs, may promote tissue regeneration.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are usually collected from the patient's bone marrow. The collected stem cells are processed in the laboratory and then injected into the area of ​​the degenerative discs. Stem cells can help restore the structural integrity of the discs and support the healing process.

  • A meniscus tear is a condition in which the meniscus, the cartilage structure in the knee joint, is damaged. The menisci are important for stabilizing the knee joint, absorbing shock, and harmonious movement of the articular surfaces. A torn meniscus can cause symptoms such as pain, swelling, locking sensation, and limitation of movement.

    Stem cell applications are being explored as a promising option in the treatment of meniscal tears. Stem cells are cells that can transform into different cells in the body and have regenerative properties. Stem cells, which have the potential to repair damage from meniscal tears and promote the healing of meniscal tissue, can promote tissue regeneration.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are usually collected from the bone marrow or adipose tissue of the patient. The collected stem cells are processed in the laboratory and then injected into the torn meniscus area. Stem cells can promote the healing of the meniscus by promoting the formation of new tissue.

  • Lateral epicondylitis is a condition commonly known as tennis elbow. This condition occurs when the tendons and muscles on the outside of the elbow become irritated by repetitive movements. Tendinopathies are conditions characterized by damage, inflammation, or degeneration of tendons. In both cases, symptoms such as pain, tenderness and loss of function may occur.

    Stem cell applications are being investigated as a promising option in the treatment of lateral epicondylitis and tendinopathies. Stem cells are cells that can transform into different cells in the body and have regenerative properties. Therefore, they have the potential to promote the healing of damaged tendons and promote tissue repair.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are usually collected from the bone marrow or adipose tissue from the patient. The harvested stem cells are processed in the laboratory and then injected into the damaged tendon area. Stem cells can help restore the health and functionality of tendons by promoting the regrowth and healing process.

  • Carpal tunnel syndrome is a condition that occurs as a result of the compression of a narrow canal called the carpal tunnel in the wrist area. This compression causes pressure on the median nerve and causes symptoms such as pain, numbness, and weakness in the hands, wrists, and fingers.

    Stem cell applications are being investigated as an alternative option for carpal tunnel syndrome. Stem cells are cells that can transform into different cells in the body and have regenerative properties. The purpose of stem cell applications in carpal tunnel syndrome is to repair the nerve damage and to relax the nerve under pressure.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are collected from the patient, usually from the adipose tissue or bone marrow. The collected stem cells are processed in the laboratory and then injected into the carpal tunnel area. Stem cells can promote the repair of nerve damage and support the nerve relaxation process.

  • Bursitis is a condition caused by inflammation of the fluid-filled sacs (bursae) near the joints that reduce friction. Bursitis may develop due to repetitive movements, trauma or infection and may cause symptoms such as pain, swelling and limitation of movement.

    Stem cell applications are being explored as a promising option in the treatment of bursitis. Stem cells are cells that can transform into different cells in the body and have regenerative properties. In the case of bursitis, the purpose of stem cell applications is to soothe the inflamed bursa, promote healing and help tissue repair.

    Stem cell applications are usually performed using the patient's own stem cells (autologous). In this process, stem cells are collected from the patient, usually from the adipose tissue or bone marrow. The harvested stem cells are processed in the laboratory and then injected into the inflamed bursa. Stem cells can support the healing process of the bursa and help relieve symptoms by reducing inflammation.

  • In the cases of all illnesses mentioned above (osteoarthritis, nonunion fractures, avascular necrosis, degenerative disc, meniscus tear, lateral epicondylitis and tendinopathies, carpal tunnel syndrome disease, and bursitis) stem cell applications are a process that requires individual evaluation for each individual. It is important that patients are informed in detail about the potential benefits, risks and limitations of stem cell applications and that the treatment process is carried out under the supervision of a specialist medical team. It is important to reach the most up-to-date information on knee health and to talk to a specialist doctor about treatment options.

    However, stem cell applications in the case of all illnesses mentioned above are not yet fully understood and indefinite results can be obtained. Some research and clinical studies show that stem cell applications can promote bone union and accelerate the healing process in patients. Since each individual's situation is different, the effectiveness of treatment may vary from person to person.

Orthopedics & Physical Therapy and Rehabilitation

Dermatology

  • Skin rejuvenation covers a series of methods to reduce the effects of the aging process and reduce wrinkles, sagging and other signs of aging on the skin. Stem cell applications have emerged as a remarkable option in skin rejuvenation recently.

    Stem cells are cells that can transform into different cells in the body and have regenerative properties. The purpose of stem cell applications in skin rejuvenation is to promote the regeneration of skin tissue, increase collagen and elastin production, and provide a young and healthy appearance to the skin.

  • Stem cell treatments can benefit non-healing wounds in a variety of ways.

    • Wound healing. Stem Cells, due to their paracrine properties, can stimulate the formation of new blood vessels and regulate the immune system by secreting growth factors and other related mediators, supporting tissue regeneration in the wound area. Such as diabetic foot, venous ulcers and Buerger's disease. Stem cell applications can help restore blood vessels in these cases. This can promote healing by providing more blood and oxygen to the wound area.

    • Reducing pain in non-healing wounds. Stem cell application can reduce inflammation and promote nerve regeneration. In this way, it may be possible for patients to observe a reduction in pain and an improvement in their quality of life.

    An important point is that stem cell applications may not be suitable for every individual. The method to be applied may vary depending on the severity of the wound, the general health of the patient and other factors. Therefore, it is important that you contact a specialist healthcare team that evaluates stem cell applications.

  • There are several different ways in which stem cells can be used for burns and burn scars. One approach is to use stem cells to create skin grafts. Skin grafts are layers of skin that are transplanted from one part of the body to another. They can be used to create skin grafts that are more compatible with the recipient's skin and less likely to reject.

    In addition, stem cells are used to deliver growth factors and other signaling molecules to the wound site. Stem cells can help speed up the healing process and improve the quality of scar tissue by delivering growth factors to the wound site.

  • Stem cells, found in many tissues in the body, including the skin, are undifferentiated cells that have the potential to develop into a variety of different cell types.

    Fibroblasts are a type of cell found in connective tissue. They produce collagen and other proteins that help keep the skin strong and elastic.

    Fibroblast banking is the process of collecting and storing fibroblasts for future use. Fibroblasts can be used in a variety of ways, including:

    • Burns and scars: Fibroblasts can be used to create skin grafts or to deliver growth factors to the wound site.

    • Regenerate damaged tissue: Fibroblasts can be used to repair damaged tissue such as cartilage or bone.

  • There are several different ways in which stem cells can be used to fill in skin deformities. One approach is to use stem cells to create skin grafts. Skin grafts are layers of skin that are transplanted from one part of the body to another. Stem cells can be used to create skin grafts that are more compatible with the recipient's skin and less likely to reject.

    Another approach is to use stem cells to deliver growth factors and other signaling molecules to the wound site. Growth factors are proteins that help support cell growth and repair. Stem cells can help speed up the healing process and improve the quality of scar tissue by delivering growth factors to the wound site.

    Stem cell application is still a relatively new method for filling skin deformities. However, there is some evidence that it can be an effective practice. In a small clinical study, patients who received a stem cell application to fill in skin deformities had significantly better results than patients who received standard treatment.

  • If you are considering stem cell applications for skin rejuvenation, non-healing wounds, burns or burn scars, fibroblast banking, and filling of shape deformities, it is essential to talk to your doctor about the risks and benefits of these applications. Your doctor will help you determine if these treatments are right for you.

    However, it is essential to remember that the treatments may differ for each patient and should be evaluated by a specialist.

Ophthalmology

  • Macular degeneration is one of the most common causes of age-related vision loss, and stem cell applications have significant potential in this disease.

    The macula is a region located at the center of the eye's retina, responsible for our clear vision. However, the aging process and other factors can cause degenerative changes affecting the macula. This condition can lead to symptoms such as blurred central vision, lines appearing curved, and ultimately vision loss. There are two main types: "dry" and "wet" macular degeneration.

    Stem cell applications are emerging as a new approach to macular degeneration. Stem cells are unspecialized cells that play a fundamental role in forming different tissues and organs in our body. In macular degeneration, stem cells can be used to repair damaged tissue on the retina and recreate the lost cells.

    Stem cell application is a complex process involving a series of steps. First, a surgical procedure is performed to place stem cells on the damaged areas of the retina. These cells effectively integrate to create new retina cells and repair damaged tissue. As a result, visual functions generally improve or stabilize.

    However, stem cell applications are still in the development phase, and clinical trials are ongoing. This treatment method may not be suitable for every patient, and individual results may vary. More research and study are needed about the efficacy, safety, and long-term results of applications.

    It is important to consult an eye specialist before deciding on any application option. Specialists will guide you to determine the most suitable application for your condition.

  • The cornea is the transparent outer layer of the eye and plays an important role in our clear vision. Corneal damage can occur from various factors, such as trauma, infections, or some diseases. Stem cell applications are considered a promising option for corneal damage.

    What is corneal damage? Corneal damage occurs when the cornea is damaged or injured. This damage can affect the cornea's transparency, leading to blurred vision, improper light refraction, or even vision loss. Corneal damage can occur in different ways, for example, wounds, scratches, ulcers on the corneal surface, or permanent thinning in the corneal layer.

    Stem cell applications are emerging as a new approach to corneal damage. Stem cells are unspecialized cells that play a fundamental role in forming different tissues and organs in our body. In corneal damage, the use of stem cells is considered to repair the damaged cornea, promote the growth of healthy cells, and regain transparency.

    How is stem cell application performed? For corneal damage, there are two primary options among stem cell sources: your own stem cells (autologous) or donor stem cells (allograft) obtained from another source. Autologous stem cells are taken from the patient's own body, while allograft stem cells can be obtained from another person or a cell bank.

    Stem cell application usually involves a series of steps. First, stem cells are placed on the damaged cornea. These stem cells effectively work to help repair damaged tissue, recreate the corneal surface smoothly, and restore transparency. This process is typically a surgical procedure performed under local anesthesia.

    Stem cell applications can provide promising results for corneal damage. However, this method is still actively researched and developed. It may not be suitable for every patient, and individual results may vary. A specialist eye doctor will guide you in determining the most suitable treatment option for your situation.

    This web page describes the current status and future potential of stem cell applications related to corneal damage. However, please remember that the information provided here does not replace medical advice. It's important to consult an eye specialist before deciding on any application option. Specialists will assist you in determining the most suitable application for you and provide information about potential risks and benefits.

  • Retinitis pigmentosa (RP) is a genetic eye disease that leads to vision loss over time. Stem cell applications are considered a promising option for this disease.

    Retinitis pigmentosa is characterized by the gradual damage to the light-sensing tissue at the back of the eye called the retina. This disease typically arises from a genetic disorder and generally results in night blindness, narrowing of the field of vision, and eventually vision loss. RP is a process that leads to the death of retinal cells and the loss of retinal function over time.

    Stem cell applications are emerging as a promising approach for retinitis pigmentosa. Stem cells are unspecialized cells that play a fundamental role in the formation of different tissues and organs in our body. In retinitis pigmentosa, the use of stem cells is being evaluated to repair damaged retinal tissue, regenerate lost cells, and improve visual function.

    How is stem cell application carried out? There are different options among stem cell sources for retinitis pigmentosa. These include embryonic stem cells, adult stem cells, and reprogrammed stem cells. Embryonic stem cells are obtained from human embryos, adult stem cells are isolated from different tissues in our body, and reprogrammed stem cells are obtained by converting mature cells back.

    Stem cell application generally consists of a series of steps. Firstly, stem cells are placed on the retina. These stem cells effectively integrate to replace lost or damaged retinal cells and restore visual function. This process is usually performed with a surgical procedure.

    However, stem cell applications for retinitis pigmentosa are still in the experimental stage and clinical trials are ongoing. It may not be suitable for every patient and individual results may vary. Therefore, it's important to consult with an eye specialist and get detailed information about treatment options.

    This webpage discusses the current status and future potential of stem cell applications related to retinitis pigmentosa. However, please remember that the information provided here does not replace medical advice. It is important to consult with an eye specialist before deciding on any application. Experts will guide you in determining the most suitable option for you and inform you about the potential risks and benefits.

*The information on this webpage does not replace medical advice. The information provided here is intended to provide a general understanding. Please consult your doctor for the condition of your disease and the most suitable application for you.

Stem Cells: A Historical and Clinical Overview

Early Beginnings:

1878: Initial attempts to fertilize mammalian eggs reveal the totipotent nature of early embryonic cells – they have the potential to form a whole organism.

1939: The first human bone marrow transplant experiment was undertaken but failed. However, Jacobson et al. in 1949 reported successful outcomes.

1950s: Following WWII's aftermath, Reckers and colleagues commenced studies on hematopoietic stem cells in mice for radiation protection.

Understanding Stem Cell Types:

Totipotent Cells: Transform into any cell type or entire organism.

Pluripotent Cells: Differentiate into the three germ layers: ectoderm, mesoderm, and endoderm.

Multipotent Cells: Become cells of a single tissue or germ layer.

Oligopotent Cells: Differentiate into a few cell types.

Unipotent Cells: Turn into a single cell type.

As cells differentiate, their potential narrows from forming organisms to specific tissues or organs.

Notable Milestones:

1960s: Discovery of hematopoietic stem cells. Pioneering stem cell studies were conducted by Prof. Dr. Süreyya Tahsin Aygün who explored fetal and cord blood graft treatments.

1967: Cultivation of embryonal carcinoma cells marks a significant step. Multiple cell lines were later derived from teratocarcinomas.

1998: The first human embryonic stem cells were cultured, paving the way for regenerative medicine but also igniting ethical debates. This led researchers to focus on adult stem cells, which had fewer ethical constraints.

Adult Stem Cells:

Defined as cells that can proliferate and differentiate into various tissue cells. Unlike specialized cells, stem cells respond to signals that activate genes for differentiation.

Sources include bone marrow, placenta, umbilical cord blood, and tissues with high regeneration like skin and intestinal epithelium (Güneş, 2005).

These cells have "plasticity", meaning they can potentially differentiate into various tissue types, a phenomenon exemplified by bone marrow stem cells transforming into skeletal muscle cells (Ferrari et al., 1998).

They hold promise for treating diseases like diabetes, Parkinson's, congestive heart diseases, bone disorders, and liver failure (Henningson et al., 2003; Lechner and Habener, 2003).

Current Applications and Research:

Adult stem cells are essential for tissue balance, replacing damaged cells due to injury or disease.

Clinical applications span across tissues, from heart to brain, skin, and digestive system (Korbling et al., 2003; Şahin et al., 2005; Yasuaki et al., 2010).

For about 30 years, bone marrow stem cells have been a gold standard in transplantation.

Conclusion:

Stem cell research, rich in history and potential, offers promise for numerous medical conditions. Ethical debates centered on embryonic stem cells have shifted the focus to adult stem cells. Continued research is vital for optimizing treatment possibilities in regenerative medicine.

  • Abbott JD., Giordano FJ., 2003. Stem cells and cardiovascular disease. J. Nucl. Cardiol., 10, 403-412.

    Anonymous, 2012. http://www.ggacademia.com/default. aspx?pid=54468 *Accessed: 20.11.2012

    Atar E., 2004. Current status in stem cells and cord blood collection. TJD Post-Specialty Education Journal, 6.58-64.

    Blau HM., Brazelton TR., Weimann JM., 2001. The evolving concept of a stem cell: Entity or function. Cell, 105, 829-841.

    Cancedda R., Bianchi G., Derubeis A., Quarto R., 2003. Cell therapy for bone disease: a review of current status. Stem Cells, 21, 610-619.

    Coulombel L., 2003. Adult tissue stem cells: definition, identification and therapeutic use. J. Annu. Diabetol. Hotel Dieu., 1-16.

    Çetiner M., 2006. History of Cellular Therapies and Süreyya Tahsin Aygün. 2nd National Stem Cell Congress Program and Summary Book, Trabzon, Pages;29-34.

    Di Campli C., Nestola M., Piscaglia AC., Santoliquido A., Gasbarrini G., Pola P., Gasbarrini A., 2003. Cellbased therapy for liver diseases. EUR. Rev. Med. Pharmacol. Sci., 7, 41-44.

    Ferrari G., Cusella DE., Angelis G., 1998. Muscle regeneration by bone marrow-derived myogenic progenitors. Science, 279, 1528-1530.

    Filip S., Okry JM., Ruska IH., 2003. Adult stemcells and their importance in cell therapy. Folio Biol. (Praha), 49, 9-14. Fuchs E., Tumbar T., Guasch G., 2004.

    Socializing with the neighbors: Stem cells and their niche. Cell, 116, 769-778. Sun AM., 2005.

    Stem cell plasticity and its uses in medicine, Current Pediatrics, 36-42.

    Hayashi S., Azuma J., Ogihara T., Morishita R., 2003. Gene therapy for myocardial regeneration. Nippon Rinsho., 61,867-870.

    Henningson CT., Stanislaus JR., Gewirtz AM., 2003. Embryonic and adult stem cell therapy. J. Allergy Clinic. Immunol., 111, S745-753.

    Korbling M., Estrov Z., 2003. Adult stem cells for tissue repair a new therapeutic concept? N. Engl. J. Med., 349, 570-582.

    Lechner A., ​​Habener JF., 2003. Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus. am. J. Physiol. endocrinol. Metab., 284, 259-266.

    Linazasoro G., 2003. Stem cells: solution to the problem of transplants in Parkinson's disease? Neurology, 18, 74-100.

    Olcay A., Nişancı Y., Sezer M., Özsaruhan Ö., 2003.

    Current stem cell applications in cardiology. Turkish Cardiole. derv. Res., 31,776-780. Şahin F., Saydam G., Omay SB., 2005. Stem cell plasticity and stem cell therapy in clinical practice. Turkish. J. Hematol. Oncol., 15.48-56.

    Térèse M., 2002. History of haematopoietic stem-cell transplantation. Nat. Rev. Cancer, 2, 231-238.

    Timothy JN., Almudena MF., Satsuki Y., Carmen PT., Yasuhiro I., Andre T., 2009. Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation, 120, 408-416.

    Turkish Academy of Sciences, 2004. Current Concepts in Stem Cell Research, Turkish Academy of Sciences Reports, Issue; 7. Ural AU., 2006. Stem cells, TOTBID Journal, 5, 140-145.

    Yasuaki O., Yasuhide Y., Hiroe O., Mika T., Yoshihiro K., Mari S., Yoko K., Koji H., Shigeru S., Katsuhisa H., Shunsuke Y., Hajime O., 2010. Induction of pluripotent stem cells from human third molar mesenchymal stromal cells. J. Biol. Chem., 285, 29270-29278.