Mesenchymal Stem Cell-Derived Exosome

Mesenchymal Stem Cell-Derived Exosome

Dermatology & Hair

What are Mesenchymal Stem Cell-Derived Exosomes?

Exosomes, nanoscale extracellular vesicles derived from Mesenchymal Stem Cells (MSCs), serve as vital paracrine mediators. These minuscule protein vesicles are enriched with functional cargos, including mRNA and mRNA molecules, peptides, proteins, cytokines, and lipids. Packed with potent growth factors, exosomes play a crucial role in catalyzing cellular and biochemical processes vital for skin rejuvenation and cellular renewal.

Major application areas of mesenchymal stem cell-derived exosomes include:

  • Spot Treatment

  • Acne Scar Treatments

  • Skin Rejuvenation

  • Atopic Dermatitis/Eczema

  • Wound Healing

  • Burn Treatment

  • Medical Solutions Against Hair Loss

  • Stem Cell Supported Skin Applications

Benefits

  • Stimulate cell proliferation and migration.

  • Enhance angiogenesis.

  • Regulate inflammation and immune responses.

  • Rejuvenate skin tissue.

  • Reduce scar tissue.

  • Shorten healing time after cosmetic procedures.

Stem cell-supported exosomes are one of the preferred methods for increasing success after hair transplantation, and they also address issues such as hair thinning and shedding. Stem cells have the ability to renew skin tissue by dividing into their own cell types. Thus, it is possible to have a healthily glowing skin and hair resistant to all effects of time.

Patients Who Underwent Exosome Treatment:

How Are Exosomes Produced?
Cells obtained from the tissue of a newborn's umbilical cord are multiplied in special culture dishes along with cell-specific nutrients. Dead cell residues are removed from the culture medium of the proliferated cells. After the preprocessing steps, exosomes are isolated by spinning at high speed using an ultracentrifuge. Once the obtained exosomes pass quality control tests, the product is prepared for use and stored under appropriate conditions.

Exosomes: The Intricate Cellular Messengers

Cells in the body communicate through various systems, including the nervous, hormonal, and immune systems. Introduced in the 1990s, exosomes are tiny vesicles (30-150 nm) secreted by cells into their surroundings. Their communication mechanism is intricate and involves processes like binding, receptor activation, internalization, fusion, and cargo transfer, resulting in functional effects. These processes are vital in numerous pathological and physiological conditions, such as immune responses, tissue repair, and cancer progression. Notably, exosomes can traverse the blood-brain barrier, offering promising avenues in treating neurodegenerative diseases, spinal cord injuries, strokes, and brain injuries by harnessing the potential of Mesenchymal Stem Cell (MSC) migration and hijacking the neural stem cell communication system.

However, the body also uses these vesicles in disease propagation, transmitting damaged proteins and genetic information linked to conditions like dementia, Parkinson’s disease, metabolic disorders, and even cancer.